L-Glutamine is an essential amino acid required by virtually all mammalian and insect cells grown in culture.

It is a crucial component of many cell culture media and serves as a major energy source for cells in culture.

L-Glutamine is very stable as a dry powder and as a frozen solution.

However, in liquid media or stock solutions, L-Glutamine can degrade relatively rapidly. 

L-Glutamine is also more labile in cell culture solution than other amino acids. 

Dipeptide derivatives of L-Glutamine (Stable Glutamine) prevent the intramolecular cyclization reaction associated with solutions of L-Glutamine. 

These derivatives are therefore stable in solution and allow the formulation of cell culture media containing L-Glutamine that may be stored at 4°C for extended periods.

Solutions containing these derivatives can even be autoclaved without appreciable degradation of the product (30 minutes at 121°C results in <5% loss of the product).

The dipeptide derivatives are metabolized within the cells to yield L-Glutamine plus the second amino acid.

This results in a more consistent delivery of L-Glutamine to cells and avoids toxic build-up of ammonia in cell cultures.

This feature can be especially important for ammonia-sensitive cell lines.

  • Volume : 100 ml
  • Storage : - 20 °C
  • Cat. No. : G0305-100ML
  • Shelf Life : 24 Months
  • Sterility : Sterile Filtered
  • State : Frozen

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